Contributions of Four Cortex Lytic Enzymes to Germination of Bacillus anthracis Spores
نویسندگان
چکیده
منابع مشابه
Contributions of four cortex lytic enzymes to germination of Bacillus anthracis spores.
Bacterial spores remain dormant and highly resistant to environmental stress until they germinate. Completion of germination requires the degradation of spore cortex peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four GSLEs: CwlJ1, CwlJ2, SleB, and SleL. In this study, the cooperative action of all four GSLEs in vivo was investigated by combining in-frame de...
متن کاملCortex peptidoglycan lytic activity in germinating Bacillus anthracis spores.
Bacterial endospore dormancy and resistance properties depend on the relative dehydration of the spore core, which is maintained by the spore membrane and its surrounding cortex peptidoglycan wall. During spore germination, the cortex peptidoglycan is rapidly hydrolyzed by lytic enzymes packaged into the dormant spore. The peptidoglycan structures in both dormant and germinating Bacillus anthra...
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The behavior of bacteria subjected to the influence of mutating agents has been studied in considerable detail, but the interpretation of the results is still largely dependent on analogy to those obtained with higher forms. The lack of clear-cut cytological evidence of a nuclear cycle has been a handicap to the bacteriologist. Studies with Tradescantia microspores by Sax (1940) showed consider...
متن کاملRoles of germination-specific lytic enzymes CwlJ and SleB in Bacillus anthracis.
The structural characteristics of a spore enable it to withstand stresses that typically kill a vegetative cell. Spores remain dormant until small molecule signals induce them to germinate into vegetative bacilli. Germination requires degradation of the thick cortical peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four putative GSLEs, based upon sequence sim...
متن کاملRole of YpeB in cortex hydrolysis during germination of Bacillus anthracis spores.
The infectious agent of the disease anthrax is the spore of Bacillus anthracis. Bacterial spores are extremely resistant to environmental stresses, which greatly hinders spore decontamination efforts. The spore cortex, a thick layer of modified peptidoglycan, contributes to spore dormancy and resistance by maintaining the low water content of the spore core. The cortex is degraded by germinatio...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2010
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01380-09